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- W2378910301 abstract "Objective:To assess the incidence of apoptosis in epiretinal membranes from eyes with proliferative vitreoretinopathy(PVR),proliferative diabetic retinopathy (PDR),and macular pucker (MP) and to further investigate the potential involvement of key executors of apoptosis.Methods:Epiretinal membranes were obtained from the eyes of twenty three patients who underwent vitrectomy surgery for recurrent retinal detachment due to PVR(n=16),traction retinal detachment due to PDR (n=5),and macular pucker (n=2).Apoptosis was assessed by TUNEL (terminal deoxynucleotidyl transfrase dUTP nick end labeling).The expression of caspase 3 and PARP (poly ADP ribose polymerase) were detected using the specific antibodies against activated caspase 3 and p85 fragment of PARP.Cytokeratin and activated caspase 3/PARP,GFAP (glial fibrillary acidic protein) and activated caspase 3/PARP double staining were used to identify cell types in the membranes.Results:Apoptotic nuclei were seen more frequently in chronic retinal detachments of greater than two months duration but the difference compared to shorter term retinal detachments was not statistically significant (P=0 19).The apoptosis indices determined for PVR (2 3%),PDR (3 4%) and macular pucker (5 5%) were not significantly different ANOVA,(P=0 41).Apoptotic nuclei were correlated increased with expression of caspase 3 and PARP.Many apoptotic cells appeared to derive from retinal pigment epithelium cells.Conclusion:Cell proliferation and apoptosis appear to be key mechanisms regulating certain cell populations in epiretinal membranes of PVR,PDR and macular pucker.Inhibition of proliferative regulators such as PCNA and/or activation of apoptotic executors such as caspase 3 may serve as therapeutic targets to halt progression of proliferative retinal disorders." @default.
- W2378910301 created "2016-06-24" @default.
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- W2378910301 date "2003-01-01" @default.
- W2378910301 modified "2023-09-23" @default.
- W2378910301 title "The signal transduction pathway of apoptosis on proliferative vitreous disorders" @default.
- W2378910301 hasPublicationYear "2003" @default.
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