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- W2378922209 abstract "Objective To observe the effect of Guizhi Fuling capsule on artery matrix in rats with atherosclerosis(AS).Methods Fifty Sprague-Dawley(SD) rats were randomly divided into control group(n=12) and AS model group(n=38).The rats in control group were fed with ordinary diet,while the rats in AS model group were given with high cholesterol diet and intraperitoneal injection of vitamin D3.The models were randomly divided into AS group(n=12),western medicine group(n=12) and observation group(n=12),the rats in the three groups were given with normal saline,simvastatin and captopril,Guizhi Fuling capsule,respectively.The rats were killed at the 16th weekend.The expressions of intercellular adhesion molecule-1(ICAM-1),matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) in aorta were detected by immunohistochemical method.Results Compared with control group,the levels of total cholesterol(TC),triglyceride(TG) and low density lipoprotein cholesterol(LDL-C) in AS model group were significantly higher(P0.05),and the level of high density lipoprotein cholesterol(HDL-C) was significantly lower(P0.05).Compared with AS model group,the levels of TC,TG and LDL-C decreased significantly(P0.05),and the level of HDL-C increased in western medicine group(P0.05).There was no statistically significant difference in levels of TC,TG,LDL-C and HDL-C between observation group and AS model group(P0.05).The positive expressions of ICAM-1 and MMP-9 in AS model group were significantly higher than those in control group,western medicine group and observation group(P0.05).The positive expressions of ICAM-1 and MMP-9 in western medicine group and observation group were significantly higher than those in control group(P0.05).There was no statistically significant difference in the positive expression of ICAM-1 and MMP-9 between western medicine group and observation group(P0.05).The positive expression of TIMP-1 in AS model group was higher than that in control group(P0.05),and the positive expressions of TIMP-1 in western medicine group and observation group were significantly higher than that in AS model group(P0.05),but there was no statistically significant difference in the positive expression of TIMP-1 between western medicine group and observation group(P0.05).Conclusion Guizhi Fuling capsule has the effect of anti-atherosclerosis on AS in rats." @default.
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- W2378922209 date "2012-01-01" @default.
- W2378922209 modified "2023-09-24" @default.
- W2378922209 title "Effect of Guizhi Fuling capsule on artery matrix in rats with atherosclerosis" @default.
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