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- W2378968553 abstract "Objective To study the special inhibition effect of P-pg expressed ovarian cancer cells on the MDR1 gene by MDR1 targeted siRNA,and offer experimental evidence for the feasibility of the ovarian cancer multidrug resistance reversal by siRNA.Methods Three MDR1 targeted siRNAs were designed and synthesized separately.After transfected into SKOV3/AR 48 and 72 hours,the RT-PCR and flow cytometry were used respectively to determine the expression of mRNA and P-gp of MDR1.MTT assay was applied to check the drug sensitivity of adriamycin and paclitaxel before and after transfection.Results The expression level of MDR1 mRNA all significantly decreased in every siRNA team(P0.05),and the inhibition ratio showed 43.3%,41.3% and 58.5% respectively,while no distinct change was found in the lipofectemine team.Compared to the blank team,negtive control team and lipofectemine team didn't show significant decline,and P-pg level in the siRNA-3 team reduced 37.95%(P0.05).The IC50 of adriamycin and paclitaxel declined 3.56 and 3 folds after siRNA-3 transfected into SKOV/AR cells,respectively.Conclusion RNAi can reverse the ovarian cancer multidrug resistance in vitro,and may provide evidence for solid tumor drug resistance reversal in the future." @default.
- W2378968553 created "2016-06-24" @default.
- W2378968553 creator A5082857738 @default.
- W2378968553 date "2010-01-01" @default.
- W2378968553 modified "2023-09-23" @default.
- W2378968553 title "Expression and reversal of multidrug resistance gene in ovarian cancer" @default.
- W2378968553 hasPublicationYear "2010" @default.
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