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- W2379008461 abstract "Objective To design by computerized molecular des ign methods therapeutic polypeptides against chronic hepatitis B infection to ex plore how to trigger HLA Ⅰrestricted HBV specific CD8 + T cell response and h ence eradicate viruses within hepatocytes. Methods A new panel of polypeptides comprised of the immunodominant CTL and B ep itopes of HBV core antigen(HBcAg) and Pre S2 protein, and the tetanus toxoid T helper epitope were synthesized,and their immunological properties were inve stigated in HLA A2 + human peri pheral blood mononuclear cells(PBMCs)and in Bal b/c mice.Results The results demonstrated that p olypeptides consist of the three kinds of epitopes could evoke in human PBMCs an d in mice CD8 + CTL response. Palm p44,a polypeptide which covalently linked p almitic acids to the carboxyl termini of the potent HBcAg CTL epitope as built in adjuvant induced vigorous CD8 + CTL response, no additional adjuvants were necessary in comparison to the free CTL epitope which failed to induce cell med iated immunity in mice. Conclusions The findings indicate that the lipidic built in adjuvant can efficiently improve the immuno genicity of peptide antigens, and Palm p44 might be a promising candidate for t herapeutic peptide vaccines against chronic viral hepatitis B infection." @default.
- W2379008461 created "2016-06-24" @default.
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- W2379008461 date "2003-01-01" @default.
- W2379008461 modified "2023-09-25" @default.
- W2379008461 title "Therapeutic peptides based on HBcAg_(18-27) epitope can induce CT L response in vitro and in vivo" @default.
- W2379008461 hasPublicationYear "2003" @default.
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