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- W2379010710 abstract "Aim:To study the relation of tinidazole concentration in plasma and saliva. Methods: The relation of tinidazole in plasma and saliva was investigated in a crossover trial in eight healthy volunteers after oral administration of 2 g tinidazole capsule and tinidazole tablets. The concentration of tinidazole in plasma and saliva were measured by HPLC method. Results: Experimental results indicated: for tinidazole capsule, the plasma and saliva t 1/2ka were (0.47±0.24),(0.63±0.38)h; t 1/2ke were (13.71±1 52),(13.78±3.37)h;the peak concentration were (52.07±9.11),(48.10±8.01)μg/mL;AUC were (1 092.98±111.83),(1 011.28±115.20) (μg·h/mL) respectively; for tinidazole tablets, the plasma and saliva t 1/2ka were (0.86±0.67),(0.78±0.52)h; t 1/2ke were (14.19±1.95,13.00± 2.07 )h; the peak concentration were (51.07±10.32),(49.09±9.27)μg/mL;AUC were (1 123.00±128.25),( 1 044.15 ±179.54(μg·h/mL) respectively. Conclusion: There were no significant difference between pharmacokinetic parameters of tinidazole in plasma and saliva. The saliva concentration were closely related with plasma concentration." @default.
- W2379010710 created "2016-06-24" @default.
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- W2379010710 date "1999-01-01" @default.
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- W2379010710 title "Relation of tinidazole concentration in plasma and saliva" @default.
- W2379010710 hasPublicationYear "1999" @default.
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