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- W2379040836 abstract "In order to obtain a sustained-release aspirin derivative,starch-aspirin conjugation was synthesized by coupling between starch and acetoxybenzoyl chloride. Its structure was characterized with1H-NMR. The drug-loading ratio of product was measured by ultraviolet spectrophotometer. And in vitro drug release investigation was carried out in artificial gastric juice and artificial intestinal juice. The results clearly showed that aspirin was coupled with the starch molecule successfully and the drug release rate of the conjugatation was nearly zero order without abrupt release. Compared with aspirin,the effective therapeutic time of the polymer prodrug was prolonged. So it may lead to less side-effect and relieving stimulation on gastrointestinal tract." @default.
- W2379040836 created "2016-06-24" @default.
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- W2379040836 date "2014-01-01" @default.
- W2379040836 modified "2023-09-23" @default.
- W2379040836 title "Synthesis and in vitro drug release of starch aspirin as macromolecular prodrug" @default.
- W2379040836 hasPublicationYear "2014" @default.
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