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- W2379069551 abstract "Objective To evaluate the optimum dose and time of neostigmine against vecuronium-induced neuromuscular blockade.Methods Neostigmine was administrated while neuromuscular transmission was blocked and no activity of peripheral nerves could be induced by using a continuous infusion of vecuronium,60 patient were randomized into 3 groups,with 20 patient in each group.Group A received neostigmine 0.015mg/kg and atropine 0.15mg,in advance and when T_1 value recovered to 10%,neostigmine 0.035mg/kg and atropine 0.25mg,Group B received neostigmine 0.035mg/kg and atropine 0.25mg, when T_1 va lues had recovered to 10%.We recorded the time from the ceasion of vecuronium infusion to the recovery of T_1 to 90%.TOF to 70% and 90%,and T_1 value and TOF ratio at 15 minutes after operation.Results Recovery of T_1 to 90%,TOF to 70% and 90% in group A were faster than those in group B、C(P0.01,P0.05,respectively),T_1 value and TOF ratio in group A at 15 minutes after operation were also higher than those in other two groups(P0.01).Conclusion Dose and time of neuromuscular administration can affect the anatgonism effect to vecuronium-induced neuromuscular blockade." @default.
- W2379069551 created "2016-06-24" @default.
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- W2379069551 date "2005-01-01" @default.
- W2379069551 modified "2023-09-23" @default.
- W2379069551 title "Optimum Dose and Time of Neostigmine against Vecuronium-induced Neuromuscular Blockade" @default.
- W2379069551 hasPublicationYear "2005" @default.
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