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- W2379071711 abstract "Objective: To explore the serum transforming growth factor-β1(TGF-β1) and bone morphogenetic protein-7(BMP-7) level in patients with prehypertension and its clinical significance.Methods: 386 patients with prehypertension and 596 with normal arterial pressure were enrolled.Serum TGF-β1 and BMP-7 level were measured by enzyme-linked immunosobent assay(ELISA).Body mass index,uric acid,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,fasting blood glucose,total cholesterol,triglyceride were determined.Results: The serum TGF-β1 level in patients with prehypertension was significantly higher than that in the men with normal arteria pressure(P0.05).The serum BMP-7 level in patients with prehypertension was significantly lower than that in the men with normal arterial pressure(P0.05).Related analysis showed that the serum TGF-β1 and BMP-7 level with systolic blood pressure,diastolic blood pressure,pluse pressure,mean arterial pressure were not significantly correlated(P0.05).Multiple linear regression analysis showed TGF-β1 and BMP-7 were influenced by glucose,lipids,systolic blood pressure.Conclusions:Serum TGF-β1 level is elevated,however serum BMP-7 level is reduced in patients with prehypertension.TGF-β1 and BMP-7 may contribute to the development of target-organ damage,independent of blood pressure." @default.
- W2379071711 created "2016-06-24" @default.
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- W2379071711 date "2013-01-01" @default.
- W2379071711 modified "2023-09-23" @default.
- W2379071711 title "Serum transforming growth factor-β1 and bone morphogenetic protein-7 level in the patients with prehypertension" @default.
- W2379071711 hasPublicationYear "2013" @default.
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