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- W2379099095 abstract "OBJECTIVE: To explore the regulation on cytokines Th1/Th2 of Shenqi Fuzheng injection,and observe its effect on survival time and its possible mechanism.METHODS: Tumor bearing Wistar rats were given Shenqi Fuzheng injection and cisplatin respectively,and the model group and normal rats were taken as the control groups.Th1,Th2 and Th1/Th2 were tested by flow cytometry and the contents of IFN-γ and IL-4 in peripheral blood were tested by ELISA.RESULTS: Th1/ Th2 of the Shenqi Fuzheng injection group and cisplatin group increased greatly,P0.01,but that in the cisplatin group still decreased significantly compared with the normal group,P0.05.IL-4 of the Shenqi Fuzheng injection group decreased significantly compared with the model group and cisplatin group(P0.01),but IFN-γ increased greatly,P0.01.The survival time of the Shenqi Fuzheng injection group prolonged significantly compared with the model group and cisplatin group,P0.01.CONCLUSIONS: Shenqi Fuzheng injection can increase Th1 cytokines and decrease Th2 cytodines,make Th2 shift to Th1.This might be one of the mechanisms of Shenqi Fuzheng injection prolonging the survival time of the tumor bearing rats." @default.
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- W2379099095 date "2009-01-01" @default.
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- W2379099095 title "Immunologic mechanisms of Shenqi Fuzheng injection prolonging survival time of tumor bearing rats" @default.
- W2379099095 hasPublicationYear "2009" @default.
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