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- W2379133023 abstract "Objective To investigate the effects of Pioglitazone on the optical spatial memory and hippocampal microstructure in modle of streptozotocin(STZ) intracerebroventricularly treated rates.Methods Each group of SAD rats which had been treated by intracerebroventricular STZ received Pioglitazone or 10% CMC once daily for three weeks.The spatial memory,hippocampal synaptophysin level and microstructure were observed.Results Compared with control group and treatment group, the escape latency and number of crossing in ICV STZ rats were significantly decrease, the number of neuron in hippocampus CA1 in the model group was significantly impaired, electron microscope reveales that STZ rat′s brain showed atrophy of neuron, degranulation or fragmentation of mitochondria, decrease of synapse.Conclusion sIntracerebroventricular administration of STZ could impair cognitive ability in rat through damage of synapses structures and neuron, Pioglitazone has protective effect on the injured brain." @default.
- W2379133023 created "2016-06-24" @default.
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- W2379133023 date "2009-01-01" @default.
- W2379133023 modified "2023-09-28" @default.
- W2379133023 title "Effect of Pioglitazone on the spatial memory and hippocampal structure in model of SAD rates" @default.
- W2379133023 hasPublicationYear "2009" @default.
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