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- W2379138839 abstract "Objective To investigate the influence of antisense oligodeoxynucleotide (AS-ODN) of Ki-67 gene translation initiator to the growth of human renal carcinoma cell strain and the Ki-67 gene expression.?Methods The AS-ODN was synthesized, packed with liposomes, and was then used to transfect ranal carcinoma 786-0 cell strain. Immunohistochemistry, 3?H-TdR penetrate-test and TUNEL assay were adopted to study the proliferation of renal carcinoma cells and the expression of Ki-67.?Results When the concentrantion of AS-ODN ≥10 μmol/L, TUNEL assay revealed an increase of apoptosis, 3?H-TdR penetrate-test showed a rise of incorporation rate, and immunohistochemistry showed a decrease of the expression of Ki-67 antigen.?Conclusion The AS-ODN of Ki-67 gene translation initiator can inhibit the expression of Ki-67 in human renal carcinoma 786-0 cell strain, inhibit the prolifertion and growth of cancer cells, and accelerate the apoptosis of them. The actions of the AS-ODN are dose-dependent in manner." @default.
- W2379138839 created "2016-06-24" @default.
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- W2379138839 date "2003-01-01" @default.
- W2379138839 modified "2023-09-22" @default.
- W2379138839 title "Antisense oligodeoxynucleotide suppresses the growth and expression of Ki-67 gene in human renal carcinoma cell line" @default.
- W2379138839 hasPublicationYear "2003" @default.
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