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- W2379171261 abstract "Objective: This project was designed to study the open-loop characteristics of the carotid sinus reflex (CSR) and the determination of its characteristic parameters. Methods: After the carotid sinus was isolated from the systemic circulation in anesthetized Wistar rats, the mean arterial pressure and the intracarotid sinus pressure were simultaneously recorded. Data were fitted respectively into the logistic equations with four or five parameters. The determination of the threshold and saturation was deduced on biomathmatics. Results: With the changes of the intracarotid sinus pressures, the change of mean arterial pressure was asymmetrically sigmoid. The application of the five-parameter model significantly reduced the mean squares of the fit, showing that the five-parameter logistic fit is more suitable for describing the open-loop baroreflex function than the four-parameter logistic fit. Compared with the methods described in previous literatures, the values of the threshold and saturation obtained by the method presented in the present study were closer to the observed intervals.Conclusion: Open-loop CSR may have an asymmetric sigmoidal curve,and its characteristic parameters could be re-defined." @default.
- W2379171261 created "2016-06-24" @default.
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- W2379171261 date "2002-01-01" @default.
- W2379171261 modified "2023-09-23" @default.
- W2379171261 title "Characteristics of Open-loop Carotid Sinus Baroreflex" @default.
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