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- W2379181662 abstract "Objective Programmed cell death 1(PD-1)up-regulation can impair virus-specific CD8+ T-cell responses during chronic viral infection.Whether PD-1 affects virus-specific CD8+ T cells in humans with acute viral infection and the mechanism of this effect,however,remain largely undefined.This study aimed to characterize the PD-1 expression during acute hepatitis B(AHB),and further address how the PD-1 regulates antiviral immunity in acute HBV infection.Methods HBV-specific CD8+ T cells in peripheral blood from 16 HLA-A2-positive AHB patients were quantitatively analyzed and PD-1 expression on HBV-specific CD8+ T cells were measured using flow cytometry.Intracellular IFN-γ staining was performed for analyses of the impact of PD-1 expression.Serum ALT levels,HBV markers and HBV-DNA levels were evaluated for each subject.Results All 16 AHB patients examined had multiple pentamer responses.PD-1 expression on HBV-specific CD8+ T cells was significantly up-regulated in the early phase of acute HBV infection.Blockade of PD-1 ligation enhances the amount of IFN-γ production by HBV-specific CD8+ T cells following 6-h stimulation with cognate peptide.Conclusion PD-1/PD-L1 pathway plays a role in the regulation of the function of HBV-specific CD8+ T cells at early phase of acute HBV infection and high PD-1 expression by HBV-specific CD8+ T cells appear to efficiently temper liver damage." @default.
- W2379181662 created "2016-06-24" @default.
- W2379181662 creator A5080525186 @default.
- W2379181662 date "2008-01-01" @default.
- W2379181662 modified "2023-09-25" @default.
- W2379181662 title "Characterization and clinical significance of PD-1 expression on HBV epitope-specific CD8~+ T cells in patients with acute self-limited hepatitis B" @default.
- W2379181662 hasPublicationYear "2008" @default.
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