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- W2379184555 abstract "AIM: To observe the effect of acupuncture on CD4+CD25+Foxp3(forkhead box P3)+regulatory T-cells(Treg cells) in rats with embryo implantation failure.METHODS: One hundred and forty-four pregnant rats were randomly divided into control group(N),mifepristone treatment group(M),mifepristone + acupuncture treatment group(A) and mifepristone + progestin treatment group(W).The rats in groups M,A and W were treated with mifepristonesesame oil solution on day 1,while the rats in group N were injected with the same amount of sesame oil.The Housanli(ST36) and Sanyinjiao(SP6) points were selected for acupuncture.From day 1 to the time of death,the rats in group A were fasten up and then the acupuncture was performed.Accordingly,the rats in group N and group M were only fixed,and the rats in group W were given progestin.Implanted embryos in each group were counted.The proportions of CD4+ CD25+Foxp3+Treg cells in peripheral blood and CD4+Foxp3+Treg cells in the endometrium were detected by flow cytometry.The mRNA and protein levels of Foxp3 were determined by real-time PCR and Western blotting,respectively.RESULTS: Compared with group N,the number of implanted embryos,the percentages of CD4+CD25+Foxp3+Treg cells in peripheral blood and CD4+Foxp3+Treg cells in the endometrium,and the expression of Foxp3 protein and mRNA in the endometrium were significantly decreased in group M(P 0.05).Compared with group M,the above indexes in group A and group W were significantly increased.CONCLUSION: The effect of acupuncture in rats with embryo implantation failure may be closely correlated with the modulation of CD4+CD25+Foxp3+Treg cells." @default.
- W2379184555 created "2016-06-24" @default.
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- W2379184555 date "2013-01-01" @default.
- W2379184555 modified "2023-09-24" @default.
- W2379184555 title "Effect of acupuncture on CD4~+ CD25~+ Foxp3~+ regulatory T-cells in rats of embryo implantation failure" @default.
- W2379184555 hasPublicationYear "2013" @default.
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