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- W2379191680 abstract "Objective To establish a novel rat model of the acute cholangitis of severe type (ACST). Methods A total of 26 male rats were raised as matched -pairs according to months and weight. They were randomly divided into two groups: ACST group(n=13)and shem operation group(n=13). All rats were unrestrained and underwent epidural anesthesia catheter used as the filling materials into vena jugularis externa. ACST group were established by placing epidural anesthesia catheter into common bile duct and ligated the distal bile duct, then injected LPS inside and closed the catheter. The level of common bile duct pressure was measured at 0 hour, 24 hours, 48 hours, and 72 hours after the ligation. The changes of TBIL,ALT,TNF -α were observed at 0 hour,12 hours,24 hours,48 hours after the injection. Pathological changes of liver tissues were observed at 24 hours and 72 hours. Results With the model establishing time extending, the level of common bile duct pressure increased gradually and reached (11.00±0.72) cm H2O at 72 hours postoperation. The differences at each time point were statistically significant(t=10.69, 6.21, 13.41,P0.05). Serum TBIL,ALT,TNF-αlevel in ACST group were progressive increased and higher than that of shem operation group at each time point (t=7.28, 12.04, 11.88; 10.03, 28.18, 20.55; 14.27, 20.67, 36.89,P0.05). Pathomorphological features showed that of the ACST group occurred light edema of hepatic cell and inflammatory cells infiltration at 24 hours and large patchy necrosis of liver cells with large inflammatory cells infiltration at 72 hours. The histopathologic alterations in shem operation group were basically normal at both 24 hours and 72 hours. Compared with shem operation group, liver pathological score was significantly higher than that of ACST group at 24 hours and 72 hours, the differences were statistically significant (t=5.00,7.23,P0.05).Liver tissue injury at 72 hours was more severe than that at 24 hours (t=2.84,P0.05). Conclusions The ACST model as clinical model can reflect the early course of ACST and lesions basically. It is suitable for further experimental studies on ACST postoperative." @default.
- W2379191680 created "2016-06-24" @default.
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- W2379191680 date "2013-01-01" @default.
- W2379191680 modified "2023-09-24" @default.
- W2379191680 title "Establishment of a novel rat model of severe acute cholangitis" @default.
- W2379191680 hasPublicationYear "2013" @default.
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