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- W2379203842 abstract "Objective To observe the level of insulin-like growth factor(IGF)-1 in atherosclerosis(AS)model mice and investigate the anti-AS mechanism of Dahuang Zhechong pill.Methods The mice were divided into control group,model group and low and high dose Dahuang Zhechong treated group.AS model was made by high fat feeding and low and high dose Dahuang Zhechong treated group were given 0.7 and 1.4 g/kg Dahuang zhechong pill respectively.After 12 w,the level of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),superoxide dismutase(SOD),malonaldehyde(MDA),and IGF-1 were observed.Results Compared with model group,the level of TC,TG,LDL-C in control group were lower and HDL-C was higher remarkably(P0.01,P0.05),while the level of TG and LDL-C in low dose Dahuang Zhechong treated group were lower(P0.01,P0.05)and the level of TG,TC,LDL-C in high dose Dahuang Zhechong treated group were lower than those of model group and HDL-C was higher than that of model group(P0.01,P0.05).The activity of SOD in model group was lower than that of control and Dahuang Zhechong treated group(P0.01,P0.05),and the content of MDA in model group was higher than that of control and high dose Dahuang Zhechong treated group(P0.01).The level of IGF-1 in model group was remarkably decreased than that of control and high dose Dahuang Zhechong treated group(P0.05).Conclusions Dahuang Zhechong pill could have the effect of anti-AS by increasing the level of IGF-1 and inhibiting the apoptosis of the vascular smooth muscle cell." @default.
- W2379203842 created "2016-06-24" @default.
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- W2379203842 date "2009-01-01" @default.
- W2379203842 modified "2023-09-25" @default.
- W2379203842 title "Effect of Dahuang Zhechong pill on the level of insulin-like growth factor-1 in atherosclerotic mice" @default.
- W2379203842 hasPublicationYear "2009" @default.
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