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- W2379231018 abstract "Objective To analyze the differentially expressed protein during colon cancer SW480 cell apoptosis induced by medroxyprogesterone acetate(MPA).Methods SW480 cells were treated with MPA at various concentrations(25,50 and 75 μmol/L)for 24,48 and 72 h separately,and determined for proliferation level by MTT method.The cells were treated with MPA at the above-mentioned concentrations for 48 h respectively,and analyzed for apoptosis rate and the percentages of cells at various phases of cell cycle.The cells were treated with 50 μmol/L MPA for 48 h and observed for change of structure by transmission electron microscopy.The total protein of SW480 cells was isolated by two-dimensional electrophoresis(2-DE),and the 2-DE image was analyzed by PDQUEST8.0 software.The differentially expressed proteins were identified by Agilent 1100 HPLC-Chip/MS system and by searching UniProtKB/SWISS-PORT,Homo Sapiens(Human)database.Results Obviously morphological change of apoptosis was observed by transmission electron microscopy in the SW480 cells treated with MPA.The MPA at various concentrations inhibited the proliferation and induced the apoptosis of SW480 cells significantly,each in a dosage-dependent mode.The cell apoptosis rate reached 56.15% at most.The analysis on cell cycle showed that the induction of colon cancer cell apoptosis with MPA might be related to the dosage-dependent arrest of cell cycle.A total of 7 kinds of proteins related to the apoptosis of SW480 cells,i.e.ubiquitin,LIM domain only protein3(LMO3),heat shock protein(HSP)10,soluble carrier family 22 member 11,UCHL2,NDPK-A and Laminin receptor 1,were identified.Conclusions MPA induced the apoptosis of SW480 cells,and the apoptosis-related proteins might be served as the potential biomarkers of MPA against colon cancer." @default.
- W2379231018 created "2016-06-24" @default.
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- W2379231018 date "2010-01-01" @default.
- W2379231018 modified "2023-09-23" @default.
- W2379231018 title "Medroxyprogesterone Acetate-Induced Colon Cancer SW480 Cell Apoptosis and Differentially Expressed Protein" @default.
- W2379231018 hasPublicationYear "2010" @default.
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