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- W2379231566 abstract "Objective To establish an atherosclerotic abdominal aorta restenosis model after stenting in rabbits and to study the mechanism of restenosis. Methods Atherosclerotic rabbit models were made by denudating abdominal aortic intima and constantly feeding high lipid diet(cholesterol concentration: 1.5%);then stents were implanted into atherosclerotic abdominal aorta.Histomorphologic changes of the arterial wall after stenting were shown by histomorphologic and immunohistochemical examination. Results Abdominal aortic wall was markedly thickened and stenosis of the aortic cavity was found.Aortic intima composed of high proliferating cell nuclear antigen(PCNA) expressing(IS:5.268±0.475) smooth muscle cells(SMCs),foam cells and extracellular matrix.Thickness of neointima was(1.33±0.05)mm;area of neointima was(5.78±0.23)mm2;stenosis degree was(31.02±1.91)%;and area of residual lumen was(9.67±0.18)mm2. Conclusions SMCs' proliferation in the neointima could induce the thickening of arterial wall after stenting." @default.
- W2379231566 created "2016-06-24" @default.
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- W2379231566 date "2007-01-01" @default.
- W2379231566 modified "2023-09-23" @default.
- W2379231566 title "Histomorphologic arterial wall changes after stenting in an established atherosclerotic abdominal aorta restenosis rabbit model" @default.
- W2379231566 hasPublicationYear "2007" @default.
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