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- W2379260106 abstract "Objective To study occult hepatitis B virus infection among blood donors in south Fujian province and discuss the effectiveness of methods to reduce transfusion transmission of hepatitis B virus.Methods Classify the HBV carrying risk of blood donors based on a variety of hepatitis B virus related serum markers detection.Samples with higher carrying risk were detected by single specimen using in-house nested PCR;samples with lower carrying risk were tested by the same method using a mini-pool of ten.A total of 19 360 HBsAg negative samples from blood donors were assayed.Results The rate of HBV DNA detection among HBsAg negative blood donors was 0.21% in south Fujian province(40/19 360,0.21%,95%CI:0.15—0.28%),which was defined as occult hepatitis B virus infection;anti-HBc assay has a higher positive detection rate(85%,34/40),but low positive predictive value(34/995,3.4%,95%CI:2.4%—4.7%);HBV NRAg assay has a higher positive predictive value(6/20,30%),but a low sensitivity(6/40,15%).Conclusion Thers is still a certain proportion of occult hepatitis B virus infection among blood donors under current blood screening system and more effective detection methods are needed." @default.
- W2379260106 created "2016-06-24" @default.
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- W2379260106 date "2010-01-01" @default.
- W2379260106 modified "2023-09-23" @default.
- W2379260106 title "Study of occult hepatitis B virus infection among blood donors in south Fujian province,China" @default.
- W2379260106 hasPublicationYear "2010" @default.
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