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- W2379273597 abstract "Summary. Sparteine at 10 -5 to 10 -4 g/ml increased the contraction time of rat diaphragm by a factor of 1.3, and amplitude by a factor of 2 to 3. The increase in force was transient, 15 min after drug application the amplitude began to fall, to reach 500/o of the control within 85 rain. The effects were reversible on washout. At 10 -3 g/ml the depressant action was predominant, so that the muscle ceased to contract after 5 min. All these results can be explained by the effects of sparteine on the action potential: decrease of the rates of rise and fall led to a prolonged duration of the action potential, and a progressive decrease of the amplitude. These effects caused an increase of the refractory period by a factor of 2.5. For this reason sparteine was very effective in stabilizing the membrane of muscle fibres made myotonic by reduction of extracellular chloride." @default.
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- W2379273597 date "1972-01-01" @default.
- W2379273597 modified "2023-09-27" @default.
- W2379273597 title "Effect of Sparteine on Normal and Myotonic Mammalian Skeletal Muscle" @default.
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