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- W2379291290 abstract "Objective: To observe the influence of chemotherapy to the switch of Th1/Th2 cytokines in colon neoplasms. Methods:The gene expression of Th1/Th2 cytokines was detected by RT-PCR in 35 normal controls,30 cases with colic polyposis and 67 patients with colon neoplasms before and after chemotherapy. Results:Th1 and Th2 cytokines were negative in peripheral blood from those with colic polyposis and the normal controls.The mRNA expression of IL-4,IL-6,IL-10 in PBMC from patients with colon carcinoma was obviously higher than those from colic polyposis and the normal controls(P0.05),and collected with the patients’clinical stages and differential degrees(P0.05).IFN-γ expression was negative in all patients(0/67),and the positive expression of IL-2 was only 3/67,and no relevance with the patients’clinical stages and differential degrees.After chemotherapy,the expression of Th1 and Th2 cytokines was changed obviously,which reflected by a significant enhancement in IFN-γ and IL-2expression,parallelling a substantial decrease in IL-4,IL-6,IL-10.Conclusion:The expression of Th1 and Th2 cytokines is imbalance in PBMC from patients with colon carcinoma;Chemotherapy can convert the predominant state of Th2 make it incline to the the normal state." @default.
- W2379291290 created "2016-06-24" @default.
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- W2379291290 date "2006-01-01" @default.
- W2379291290 modified "2023-09-24" @default.
- W2379291290 title "Influence and significance of chemotherapy to the gene expression of Th1 and Th2 cytokines in colon carcinoma" @default.
- W2379291290 hasPublicationYear "2006" @default.
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