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- W2379301069 abstract "Objectives: To observe changes of AQP2 expression in neonatal rats with acute renal ischemic failure and explore its pathological significance in renal tissue following ischemia and reperfusion injury(IRI).Methods: Using SD rats aging 7 days with unilateral renal ligation following clamping another renal for 30 min and slacking the clamp to restore renal perfusion for 6h and duplicate the IRI models,only false operation(sham) treatment in control group.Using transmission electron microscopy,to observe ultrastructural changes in renal tissues treated by ischemia and reperfusion.Further, to determinate Cr in serum,and to detect the expressions of AQP2 in each samples by using immunohistochemistry.Results: It showed the Cr in serum increase in neonatal rats after renal ischemia and reperfusion injury while the expression of AQP2 in the treated renal tissue was decreased significantly,lower than the control group with statistically significant difference(P 0.01).Conclusion: There was severe renal damage in neonatal rats with renal ischemia-reperfusion for 6 h,while the downregulation of AQP2 expression in renal tissues,that may be related to metabolic disorders after renal IRI tubular including inflammatory response and andcytokines,and be also involved in the process of Urinaryconcentration ability damage." @default.
- W2379301069 created "2016-06-24" @default.
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- W2379301069 date "2012-01-01" @default.
- W2379301069 modified "2023-09-23" @default.
- W2379301069 title "Changes of AQP2 expression in neonatal rats with acute renal ischemic failure" @default.
- W2379301069 hasPublicationYear "2012" @default.
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