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- W2379304760 abstract "Objective: To explore the effects of tumor cells on the development and function of the mononuclear cell (MNC) -derived dendritic cells. Methods: The supernatants of cultured cell lines H7402 (human hepatocellular carcinoma) , HCT-8 (human colon carcinoma) and HFCL (human bone marrow stromal cell) were collected and used as the conditional culture medium (CCM) for MNC-derived DC culture. The dendritic cells were characterized by phenotypic a-nalysis. We evaluated the capacity of phagocytizing dextran, and the capacity to stimulate allogeneic T cells of MNC-derived DC. Results:Phenotypic analysis showed that dendritic cells cultured in the presence of supernatants of tumor cells expressed lower levels of GDI a, MHC Ⅱ molecules (HLA-DR) and costimulatory molecules (CD86) , all of which were significantly lower than those in control and HFCL groups (the negative control group). Also, they displayed a much lower capacity of phagocytizing dextran as shown by the FITC-dextran assay. Moreover, they were less efficient of inducing allogeneic T-cell proliferation in a mixed lymphocyte reaction. Conclusion: These data show that tumor cells negatively regulate the production and function of DC, which might be one of the underlying mechanisms that play a role in the immune escape of tumor cells." @default.
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- W2379304760 date "2002-01-01" @default.
- W2379304760 modified "2023-09-25" @default.
- W2379304760 title "Suppression of the Development and Function of Dendritic Cells by the Secretion of Tumor Cells" @default.
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