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- W2379307113 abstract "Objective To investigate the suppressive effect of hLIGHT-Fc on human breast adenocarcinoma cell MCF-7 in vitro. Methods hLIGHT-Fc expression vector or pCI-neo blank vector was transfected into human breast adenocarcinoma cell line MCF-7 and normal MCF-7 cells were used as normal control. The suppressive effects of hLIGHT-Fc gene on cell growth was described by cell growth curve, MTT and flow cytometry (FCM) analysis. Results Expression of hLIGHT-Fc gene strongly inhibited MCF-7 cell proliferation in vitro. The growth of MCF-7/LIGHT was significantly lower than that of control. MTT test showed that the difference of cell viability between MCF-7/LIGHT and control cells was also significant (P0.05). FCM showed MCF-7/LIGHT cells on S phase was reduced greatly when treated with 100 μg/ml IFN-γ for 48 h and apoptosis could be observed in some cells. Conclusion The growth of human breast adenocarcinoma cell line MCF-7 can be suppressed by hLIGHT-Fc gene transfection in vitro, but its completive evaluation still needs to be furthered." @default.
- W2379307113 created "2016-06-24" @default.
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- W2379307113 date "2005-01-01" @default.
- W2379307113 modified "2023-09-25" @default.
- W2379307113 title "Effect of hLIGHT-Fc gene transfection into human breast adenocarcinoma cell line MCF-7 on proliferation in vitro" @default.
- W2379307113 hasPublicationYear "2005" @default.
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