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- W2379314829 abstract "Objective:To study the protective effect of tetramethylpyrazine on rat island flap after ischemia-reperfusion injury.Methods:One hundred and twelve SPF SD rats were given serial numbers according to the weight and then randomly divided into sham operation group(SO),the control group(IR group),tetramethylpyrazine group(TMP group) and low molecular weight dextran group(low-right group),28 in each group.Animals in each group were randomly redivided into 2 h group,4 h group,6 h group,8 h group and other subgroups.Ischemia-reperfusion model of abdominal island flap was created in the rats based on superficial epigastric vascular bundle.Flap tissues as well as blood samples were drawn for detection of malondialdehyde(MDA) content and superoxide dismutase(SOD) activity.Results:(1) MDA and SOD activity in the 6 h and 8 h IR groups as well as the endogenous SOD activity of flaps were significantly decreased.SOD activity of the flaps in 6h and 8h subgroups of TMP group and the low-right group were remarkably increased compared to IR group at the same time point(P0.05).MDA content of the flaps in the TMP group and the low-right group(6h and 8h subgroups) was lower than the IR group(P0.05).Within IR groups,SOD activity was significantly lower in 6h and 8h subgroups than that in 2h and 4h subgroups(P0.05),while MDA content increased(P0.05).(2) Endogenous SOD activity in serum was decreased in all subgroups of IR group,but it was increased significantly in 6h and 8h subgroups of TMP group and the low-right group compared to IR group at the same time point(P0.05).MDA content was significantly lower in TMP group and the low-right group than the IR group(P0.05).Among all IR groups,SOD activity was significantly decreased while MDA content increased in 6h and 8h subgroups compared with 2h and 4h subgroups(P0.05).Conclusion:Tetramethylpyrazine can lower MDA level and increase SOD activity in flap tissues,thus has a protective effect on the free flap with ischemia-reperfusion injury." @default.
- W2379314829 created "2016-06-24" @default.
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- W2379314829 date "2013-01-01" @default.
- W2379314829 modified "2023-09-23" @default.
- W2379314829 title "Study on the Changing of SOD and MDA Levels resulted from Tetramethylpyrazine in Rat Skin Flap after Ischemia-reperfusion Injury" @default.
- W2379314829 hasPublicationYear "2013" @default.
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