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- W2379333758 abstract "Objective To investigate the angiogenesis process of human pancreatic cancer cells(HPCC) and its clinical implication. Methods Cancer cells were implanted into the dorsal skinfod charnberon SCID mice and angiogenesis process was continuously observed with introvital videomicrosc0pic system fortwo weeks. Imaging analysis software was used to compare the changes in vascular area (VA), vascular density (VD) and vascular diameter. Results HPCC couId form their own new vasculature from surrounding normal microvessels in one week, and visible microtumors in the chamber could be found in two weeks. Thechanges in VD and VA were significant as compared with control group (P0. 001, P 0.01 respectively).Condusions HPCC could induce angiogenic agents which stimulate the proiferation of surmunding endothelial cells and form new tumor vasculature. Antiangiogenic therapy might be used to treat this disease. Postoperative adjuvant treatment should be given as earlier as peibIe. VD might be used as a gcod indicator of themalignant extent of human pancreatic cancer." @default.
- W2379333758 created "2016-06-24" @default.
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- W2379333758 date "1999-01-01" @default.
- W2379333758 modified "2023-09-26" @default.
- W2379333758 title "Observation of the angiogenesis process of human pancreatic cancer cells and its clinicai implication" @default.
- W2379333758 hasPublicationYear "1999" @default.
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