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- W2379341081 abstract "OBJECTIVE:The pharmacokinetics and pharmacodynamics of OME were studied in 8 healthy volunteers after an infusion dose of 80 mg domectic preparation.METHODS:Plasma concentrations of omeprazole were determined by HPLC method.24 hour intragastric pH monitoring was carried out in each subject.RESULTS:Plasma concentration time curve was fitted to a two compartment open pharmacokinetic model.24 hour mean intragastric pH and the total time of intragastric pH4 were 6.21±0.40 and (90.53±7.86)%,respectively.CONCLUSION:The results showed that OME has great inhibitory effect on gastric acid secretion ,no significant correlation was found between the degree of acid inhibition and plasma concentration." @default.
- W2379341081 created "2016-06-24" @default.
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- W2379341081 date "2000-01-01" @default.
- W2379341081 modified "2023-09-28" @default.
- W2379341081 title "STUDY ON PHARMACOKINETICS AND PHARMACODYNAMICS OF DOMESTIC OMEPRAZOLE INFUSION PREPARATION IN EIGHT HEALTHY VOLUNTEERS" @default.
- W2379341081 hasPublicationYear "2000" @default.
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