Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379348441> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2379348441 abstract "AIM:To explore the role of 78 kD glucose-regulated protein(GRP78) in the development of liver cirrhosis in rats promoted by intestinal endotoxemia(IETM).METHODS: Fifty-one male Wistar rats were randomly divided into liver cirrhosis groups of 4th-week,6th-week and 8th-week,and normal control group at the corresponding time points.The rat model of hepatic cirrhosis was induced by employing multiple pathogenic factors to the animals.The liver injury and hepatic fibrosis were observed with the staining of HE and VG,respectively.The expression of GRP78 at the mRNA and protein levels was measured by the methods of RT-PCR and immnunohistochemistry,respectively.The concentrations of alanine aminotransferase(ALT),endotoxin,TNF-α and homocystine(HCY) in plasma,and the content of TNF-α,malondialdehyde(MDA) and PⅢP in liver tissues were detected.RESULTS: As liver cirrhosis developed,the levels of ALT,endotoxin,TNF-α and HCY in plasma,the expression of GRP78 at mRNA and protein,the content of TNF-α,MDA and PⅢP in liver tissues,and the index of liver fibrosis were gradually increased and were significantly higher than those in normal control group(P0.05).Elevated endotoxin in plasma was correlated positively with the protein expression of GRP78,the content of MDA and HCY in plasma and the index of liver fibrosis(P0.01).Elevated protein expression of GRP78 was correlated positively with the content of MDA and HCY in plasma and the index of liver fibrosis(P0.01).CONCLUSION: GRP78 plays an important role in the development of liver cirrhosis.Endoplasmic reticulum stress is a possible mechanism in the development of liver cirrhosis promoted by IETM." @default.
- W2379348441 created "2016-06-24" @default.
- W2379348441 creator A5086472811 @default.
- W2379348441 date "2010-01-01" @default.
- W2379348441 modified "2023-09-28" @default.
- W2379348441 title "Role of 78 kD glucose-regulated protein in the development of liver cirrhosis promoted by intestinal endotoxemia in rats" @default.
- W2379348441 hasPublicationYear "2010" @default.
- W2379348441 type Work @default.
- W2379348441 sameAs 2379348441 @default.
- W2379348441 citedByCount "0" @default.
- W2379348441 crossrefType "journal-article" @default.
- W2379348441 hasAuthorship W2379348441A5086472811 @default.
- W2379348441 hasConcept C104317684 @default.
- W2379348441 hasConcept C105580179 @default.
- W2379348441 hasConcept C126322002 @default.
- W2379348441 hasConcept C134018914 @default.
- W2379348441 hasConcept C2776151105 @default.
- W2379348441 hasConcept C2777214474 @default.
- W2379348441 hasConcept C2778401633 @default.
- W2379348441 hasConcept C2780559512 @default.
- W2379348441 hasConcept C2993667909 @default.
- W2379348441 hasConcept C55493867 @default.
- W2379348441 hasConcept C71924100 @default.
- W2379348441 hasConcept C86803240 @default.
- W2379348441 hasConceptScore W2379348441C104317684 @default.
- W2379348441 hasConceptScore W2379348441C105580179 @default.
- W2379348441 hasConceptScore W2379348441C126322002 @default.
- W2379348441 hasConceptScore W2379348441C134018914 @default.
- W2379348441 hasConceptScore W2379348441C2776151105 @default.
- W2379348441 hasConceptScore W2379348441C2777214474 @default.
- W2379348441 hasConceptScore W2379348441C2778401633 @default.
- W2379348441 hasConceptScore W2379348441C2780559512 @default.
- W2379348441 hasConceptScore W2379348441C2993667909 @default.
- W2379348441 hasConceptScore W2379348441C55493867 @default.
- W2379348441 hasConceptScore W2379348441C71924100 @default.
- W2379348441 hasConceptScore W2379348441C86803240 @default.
- W2379348441 hasLocation W23793484411 @default.
- W2379348441 hasOpenAccess W2379348441 @default.
- W2379348441 hasPrimaryLocation W23793484411 @default.
- W2379348441 hasRelatedWork W2052574657 @default.
- W2379348441 hasRelatedWork W2348322412 @default.
- W2379348441 hasRelatedWork W2350479845 @default.
- W2379348441 hasRelatedWork W2363267481 @default.
- W2379348441 hasRelatedWork W2365130463 @default.
- W2379348441 hasRelatedWork W2372305934 @default.
- W2379348441 hasRelatedWork W2373490722 @default.
- W2379348441 hasRelatedWork W2375800188 @default.
- W2379348441 hasRelatedWork W2376536833 @default.
- W2379348441 hasRelatedWork W2378432359 @default.
- W2379348441 hasRelatedWork W2378721360 @default.
- W2379348441 hasRelatedWork W2382473626 @default.
- W2379348441 hasRelatedWork W2386595854 @default.
- W2379348441 hasRelatedWork W2387851147 @default.
- W2379348441 hasRelatedWork W2387936238 @default.
- W2379348441 hasRelatedWork W2390642306 @default.
- W2379348441 hasRelatedWork W2392740724 @default.
- W2379348441 hasRelatedWork W2394432437 @default.
- W2379348441 hasRelatedWork W3047930825 @default.
- W2379348441 hasRelatedWork W3151772871 @default.
- W2379348441 isParatext "false" @default.
- W2379348441 isRetracted "false" @default.
- W2379348441 magId "2379348441" @default.
- W2379348441 workType "article" @default.