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- W2379353112 abstract "Objective: To investigate the role and mechanism of IL-33 in the process of turning epithelium-mesenchyme for A549 cells which is in one strain of human alveolar epithelial cells. Methods: To stimulate cultured A549 cells with TGF-β1( 5 ng/mL). MTT assay was used to assess the proliferation of the A549 cells in response to TGF-β1treatment the dynamic expressions of IL-33 /TLR4 mRNA were detected by RT-PCR. Western blotting were employed to examine the mRNA and protein expressions of α-smooth muscle actin( α-SMA) and E-cad,p-AKT. Results: The data showed that TGF-β1had no obvious effects on the proliferation of A549 cells. Stimulated by TGF-β1,E-cad expression of A549 cells gradually declined. α-SMA expression was higher. p-AKT expression gradually increased. Real-time PCR had shown that expressions of IL-33 /TLR4 mRNA increased firstly then decreased gradually. The significant differences were observed from 0 h to 24 h,especially on 24 h,compared with control group( P 0. 05). Conclusion: IL-33 /TLR4 /PI3K /AKT signal transduction pathway promoted epithelial-mesenchymal transition( EMT) of A549,especially on earlier inflammatory reaction." @default.
- W2379353112 created "2016-06-24" @default.
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- W2379353112 date "2014-01-01" @default.
- W2379353112 modified "2023-09-23" @default.
- W2379353112 title "Effect of IL-33 /TLR4 signal pathway in inducing A549 cells transition to mesenchymal cells from epithelium in vitro" @default.
- W2379353112 hasPublicationYear "2014" @default.
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