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- W2379366897 abstract "Objective To investigate the proliferation and collagen secretion of transplanted human fibroblasts.Methods The solution containing human fibroblasts(2×1010L-1)was prepared and 1 mL was injected into the dermis of BALB/CNU nude mice.Animals were killed by the end of the 1st,2nd and 3rd month after injection.The dermis in the injected area was taken out and stained with HE.Immunohistochemical staining for type I and type Ⅲ collagen was performed at the same time.Results Mitosis was observed by the end of the 1st,2nd and 3rd month.The concentration of type I and type Ⅲ collagen in the extra cellular matrix increased with the passing of time.Conclusion Transplanted human fibroblasts can proliferate automatically in the dermis of nude mice and manufacture the type I and type Ⅲ collagen in situ.Long period of survival and secretion will make it possible for fibroblasts to become promising option to correct minimal tissue defects." @default.
- W2379366897 created "2016-06-24" @default.
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- W2379366897 date "2007-01-01" @default.
- W2379366897 modified "2023-09-26" @default.
- W2379366897 title "Observation on proliferation and collagen secretion of the transplanted human fibroblasts in nude mice" @default.
- W2379366897 hasPublicationYear "2007" @default.
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