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- W2379372016 abstract "Objective The study is to investigate the effect of Arnebia euchroma(Royle)Johnst.extracts liposomes gel(AELG)on radiation-induced skin injury and related factors in rats.Methods The AELG were prepared by mixing the liposomes of extracts fromArnebia euchroma(Royle)Johnst.with gel base in different volume,and the transdermal profile were tested;the model of radiation-induced skin injury were made on the hip of rats under theβ-ray from linear accelerator.The healing time of ulcer,pathological changes of tissue,contents of hydroxyproline(hyp)in skin tissue,serium level of MDA,SOD,IL-6 and TGF-βwere tested,respectively.Results The releasing profile in viro.of gel corresponded to the Higuchi equation and the releasing rate were lowering with the increasing of liposomes amounts.The ulcer of skin appeared after 20 days′exposure under radiation of 40gry once,and the contents of hyp,serum level of MDA,IL-6 and TGF-βwere decreased,but SOD increased significantly.Being administrated the preparation of gel and AELG on the ulcer of skin,the ulcer healed within 4-5 weeks,the healing time of both groups which were administrated with gel were shorter than negative group.The contents of hyp,level of MDA,IL-6 and TGF-βwere increased,SOD were decreased,the AELG groups were better than the gel groups in terms of extents of indexes above.Conclusion AELG could promote the healing of radiation-induced skin ulcer.The mechanism may be related to the enhancement of collagen protein synthetization." @default.
- W2379372016 created "2016-06-24" @default.
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- W2379372016 date "2013-01-01" @default.
- W2379372016 modified "2023-09-26" @default.
- W2379372016 title "Effect of arnebia euchroma (Royle) johnst extracts liposomes gel on radiation-induced skin injury in rats" @default.
- W2379372016 hasPublicationYear "2013" @default.
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