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- W2379402362 abstract "The experiment was designed to investigate the variation of DAT and D2 receptor in morphine administered and 1,2,3 day abstinent rats. Morphine exposure was induced by repeated morphine (i.p.) treatment for 8 days. Conditioned place preference test was conducted to evaluate the drug seeking behaviour and morphine dependence of rats with morphine exposure. Biodistribution of the imaging agents 125I-β-CIT and 125I-IBZM was used to evaluate the central DAT and D2 receptor during morphine exposure and 1,2,3 day’s abstinence. Results reveal the following facts. (1) The morphine abstinent rats showed diarrhea and body-shake 1 day after morphine withdrawal. (2) For morphine group, 125I-β-CIT %ID/g in ST and NAC was higher than that of the 1,2,3 day’s abstinent rats and control (P0.05). No difference was found between 1,2,3 day’s abstinent group and control group (P0.05). (3) 125I-IBZM %ID/g in ST, NAC and HIP in morphine rats were lower than those of the abstinent and control rats (P0.05). The 125I-IBZM %ID/g in ST and NAC gradually increased with the abstinent days. While in ST the %ID/g among the abstinent rats was all lower than that of the control rats, in NAC the %ID/g was still lower in 1 day’s abstinent rats (P0.05), and no difference in 2 and 3 day’s abstinent rats was observed in comparison with the control (P0.05), indicating the reduction of hyper-activated DAT and the increase of down-regulatory D2 receptor induced by morphine during morphine withdrawal. Our results confirmed that the dopamine system, especially DAT and D2 receptor in mesolimbic and meso-striatum pathway, has been implicated in morphine treatment. The rewarding properties of morphine and the somatic expression of morphine abstinence were related to changes in mesolimbic and meso-striatum dopaminergic activity." @default.
- W2379402362 created "2016-06-24" @default.
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- W2379402362 date "2006-01-01" @default.
- W2379402362 modified "2023-09-27" @default.
- W2379402362 title "Exploration of central dopamine transporter and D2 receptor in morphine abstinent rats" @default.
- W2379402362 hasPublicationYear "2006" @default.
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