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- W2379403493 abstract "In autoimmune thrombocytopenic purpura (AITP) specific autoantibodies bind plate let GP via their Fab fragments. Both splenic CD5+ B and CD5-B cells produce plat elet glycoprotein-specific antibodies. There is limited number of antigenic det erminants, and the GP-specific autoantibodies are derived from a restricted num ber of B-cell clones in chronic AITP. Blocking co-stimulatory signals could in duce platelet-specific T cell anergy. MMF could be used as a second line agent for the treatment of steroid-resistant AITP. Detection of plasma thrombopoietin levels play an important role in the differentiation of thrombocytopenic states caused by platelet destruction or due to bone marrow hypoplasia. Endogenous TPO level is also important on the differential diagnosis of ET and RT. Quinine- or heparin-dependent antibodies could induce thrombocytopenia. PCR-SSP is usef ul for the genotyping of the platelet-specific alloantigen HPA. Biotinylated pl atelets have an impaired response to agonists as evidenced by in vitro plate let aggregation tests." @default.
- W2379403493 created "2016-06-24" @default.
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- W2379403493 date "2004-01-01" @default.
- W2379403493 modified "2023-09-24" @default.
- W2379403493 title "Progress of Studies on Molecular Immunology of Human Pletelets——Editorial" @default.
- W2379403493 hasPublicationYear "2004" @default.
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