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- W2379427602 abstract "AIM: To observe the effects of diethylhexylphthalate(DEHP) on testosterone synthesis in fetal Leydig cells(FLC) of newborn male rats.METHODS: The pregnant rats were exposed to DEHP at dose of 10 mg·kg-1·d-1,100 mg·kg-1·d-1 or 750 mg·kg-1·d-1(body weight) by gavage from gestation 12 days(GD 12) to postnatal 1 day(PND 1) respectively.The serum level of testosterone was detected by chemiluminescence.The morphology of FLC from the testes was observed under light microscope and transmission electron microscope.The mRNA expression of steroidogenic acute regulatory protein(StAR) and insulin-like growth factor I(IGF-I) was detected by real-time PCR(ΔΔCT).RESULTS: The serum testosterone level in low dose group was significantly higher than that in control,middle and high dose groups.The serum testosterone level in middle and high dose groups was significantly lower than that in control group(P0.05).Light microscopy showed the aggregative cluster distribution of FLCs in low dose group,while manifested as tumor-like hyperplasia of FLCs in middile dose group and high dose group.Under electron microscope,the FLC in low dose group showed oval-shape or long spindle-shape,the lipid particles were decreased,but smooth endoplasmic reticulum and mitochondria were increased in cytoplasm.In middle and high dose group,the FLC were spindle or oval-shaped,showed large or small,nuclear large,round,rich in cytoplasm and cell aggregation,the cytoplasm was rich lipid particles with deep-stained,smooth endoplasmic reticulum and mitochondria were expanded.Compared to control group,the mRNA expression of StAR in low,middle and high dose group was decreased.The mRNA expression of StAR in high dose group was decreased more significantly(P0.01) as compared to that in control group,while the mRNA expression of IGF-I in low dose group and middle dose group was increased,but that only in low dose group was increased more significantly as compared to control group(P0.01).CONCLUSION: DEHP has toxic effect on FLC and changes the morphology and steroidogenic capacity in testicular FLC.The low dose of DEHP elevates the gene expression of IGF-I,and IGF-I stimulates the production of testosterone by FLC.The high dose of DEHP may inhibit the gene expression of StAR to reduce the serum levels of testosterone." @default.
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- W2379427602 date "2010-01-01" @default.
- W2379427602 modified "2023-09-23" @default.
- W2379427602 title "Effects of DEHP on testosterone synthesis in fetal Leydig cells of newborn male rats" @default.
- W2379427602 hasPublicationYear "2010" @default.
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