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- W2379433295 abstract "Objective To investigate the effects of dendritic cell pulsed with U937 cel frozen-thawed antigen on inducing the cytotoxic T lymphocyte(CTL)to get specific anti-tumor activity in vitro. Methods DC was generated from human bone marrow mononuclear cells (BMMC)in the presence of granuloceyte/macrophage-colony stimulating factor(GM-CSF),interleukin-4(IL-4)in vitro.DCs were pulsed with U937 frozen-thawed antigen,and co-cultured to induce T cell into specific CTL.The effects of specific U937 cell killing by CTL induced by DC pulsed with U937 cell frozen-thawed antigen and the effect of the funtion and CD expression affected by dendritric cells on CTL was observed. Results The CD1a expression on DC pulsed with U937 frozen-thawed antigen increased more obviously than the uncultured (P0.01).The CD1a,CD86,CD11c and HLA-DR expression on DC pulsed with U937 frozen-thawed antigen increased more obviously than the uncultured (P0.01).There was no difference for CD86 and CD14 expression on DC pulsed with U937 frozen-thawed antigen compared to the uncultured (P0.05). There were more CD3+CD8+T cells in the CTL induced by DC pulsed with U937 frozen-thawed antigen than that in T cells uncultured (P0.01). The CTL induced by DC pulsed with U937 frozen-thawed antigen had more significant activity in U937 cells killing than K562 cell in killing(P0.01). Conclusion The DC generating from human bone mar- row mononuelear cells(BMMC) in the presence of granulocyte/macrophage-colony stimulating factor(GM-CSF),interleukin-4(IL-4) is CD14-CD1a+ DC,and it can also induce the cytotoxic T lymphocyte(CTL) to get specific anti-tumor activity in intro.Otherwise,the increasing of CD3+CD8+ T cells in the CTL induced by DC pulsed with U937 frozen-thawed antigen suggests the main role of the CD3+CD8+ T cells in the anti-tumor immunity." @default.
- W2379433295 created "2016-06-24" @default.
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- W2379433295 date "2004-01-01" @default.
- W2379433295 modified "2023-09-22" @default.
- W2379433295 title "Investigation on Specific U937 Cell Killing by CTL Induced by Dendritic Cells Pulsed with Frozen-thawed Antigen" @default.
- W2379433295 hasPublicationYear "2004" @default.
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