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- W2379450899 abstract "Background Fractalkine is involved in the impairment of endothelium by mediating inflammatory cell chemotaxis.Aspirin inhibites many kinds of cytokine expression.Objective To investigate the effect of aspirin on tumor necrosis factor α(TNF-α) stimulated fractalkine expression in human umbilical vein endothelial cells (HUVEC) and its mechanism.Methods HUVEC were grouped as follows:control group;TNF-α-stimu- lated;TNF-α+NS-398;TNF-α+PDTC and TNF plus various concentration of aspirin (0.02,0.2,1.5 mmol/L). The level of mRNA and protein expression of fractalkine and nuclear factor(NF)-kB p65 was determined by RT- PCR and Western blot.Results 1)Fractalkine mRNA and protein level was increased after 4 μg/L TNF-α stim- ulation in HUVEC(both P0.01).2)TNF-α-stimulated fractalkine mRNA and protein expression was sup- pressed by aspirin in a dose dependent manner(both P0.01).Concurrently,NF-kB p65 mRNA and protein expression was suppressed by aspirin in a dose-dependent manner(All P0.01)as well.3)PDTC a specific in- hibitor of NF-kB prevent the TNF α stimulated fractalkine mRNA and protein expression (both P0.01). Conclusion Aspirin suppresses the TNF-α-stimulated expression in HUVEC mediating NF-kB p65 pathway." @default.
- W2379450899 created "2016-06-24" @default.
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- W2379450899 date "2008-01-01" @default.
- W2379450899 modified "2023-09-23" @default.
- W2379450899 title "Aspirin Inhibits Fractalkine Expression Stimulated by Tumor Necrosis Factor α in Human Umbilical Vein Endothelial Cells" @default.
- W2379450899 hasPublicationYear "2008" @default.
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