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- W2379467795 abstract "[Purpose] To establish the models of brainstem glioma in rats and nude mice,and to investigate the feasibility of monitoring the brainstem glioma with 1.5T MRI system.[Methods] Fischer344 rats and nude mice were inoculated with rat glioma cell line F98,human glioma cell lines U251MG and U87MG into brainstem,respectively.Brainstem gliomas were followed up with a 1.5T MRI scanner.Volumes of tumor in MRI were compared with that in pathology to assess the coherence between MRI section and pathological section.The repeatability of brainstem glioma models was explored by survival analysis.[Results] Of 20 Fischer344 rats implanted with F98 glioma,brainstem glioma was formed in 18 rats,and U251MG,U87MG resulted in brainstem gliomas in 3 of 15 and 12 of 15 nude mice respectively.MRI of glioma models was consistent with the features in pathology.Volume of tumor in MRI(95.9±17.8mm3)in rats was 14.7% larger than that in pathology(81.8±20.5mm3)(t=4.78,P0.01).Volume of tumor in MRI(9.49±0.91mm3)in nude mice was 8.0% larger than that in pathology(8.79±1.15mm3)(t=3.04,P=0.01).Volume of tumor in MRI and in pathology was highly correlated(r=0.631 in rats and r=0.526 in nude mice).F98 burdened Fiscsher344 rats survived for 10 to 19 days,and 50% died in 13 to 15 days.However,survival of U87MG burdened mice ranged 21 to 41 days,and 75% survived for 24 to 31 days.[Conclusion] F98 and U87MG are suitable to establish brainstem glioma models.It is feasible to monitor the development of brainstem glioma with 1.5T MRI scanner." @default.
- W2379467795 created "2016-06-24" @default.
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- W2379467795 date "2007-01-01" @default.
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- W2379467795 title "Establishment of Brainstem Glioma Models and Their Characteristics in MRI" @default.
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