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- W2379486039 abstract "OBJECTIVE To investigate the pathogenicity's difference of ESBLs-producing Klebsiella pneunmoniae in different route of infection in mice and the protection of ceftazidime on mice infected by ESBLs-producing K.pneunmoniae through abdominal cavity.METHODS The half lethal dose of ESBLs-producing K.pneunmoniae to mice infected through nose and abdominal cavity were detected.The mice infected by ceftazidime-sensitive ESBLs-producing K.pneunmoniae through abdominal cavity were divide into 3 groups and the therapeutical effect of ceftazidime were investigated through different therapeutical methods. RESULTS All mice infected ESBLs-producing K.pneunmoniae through nose did not die.The half lethal dose of ESBLs-producing K.pneunmoniae through abdominal cavity were 10~(5).The death rate of mice infected ceftazidime-sensitive ESBLs-producing K.pneunmoniae through abdominal cavity in the ceftazidime medication administration groups of prophylaxis,simultaneous and infected 4 hours were 10%,30%,30%,respectively.The protection of ceftazidime on mice infected by ESBLs-producing K.pneunmoniae was equal with Imipenem/Cilastatin(IPM).CONCLUSION The pathogenicity's of ESBLs-producing K.pneunmoniae through respiratory infection in mice is weaker than abdominal cavity infection.Ceftazidime can treat the infection of ceftazidime-sensitive ESBLs-producing K.pneunmoniae." @default.
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- W2379486039 date "2006-01-01" @default.
- W2379486039 modified "2023-09-23" @default.
- W2379486039 title "Pathogenicity of ESBLs-producing Klebsilla pneunmoniae and analyse on therapeutic effect of ceftazidime" @default.
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