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- W2379521567 abstract "Objective To investigate on influence of CYP2D6 genetic polymorphism on pharmacokinetics of tramadol in Chinese volunteers. Methods Adult healthy Chinese volunteers with different CYP2D6 genotypes were categorized into the following four groups: group 1: CYP2D6*2W*10W, group 2: CYP2D6*2M*10W, group 3: CYP2D6*2M*10H, group 4: CYP2D6*2M*10M. After oral administration of 100 mg tramadol, plasma and urine samples were collected from each subject at different time within 32 h. The plasma and urine concentrations of tramadol and its metabolite O-desmethyltramadol (M1) were determined by HPLC with fluorescence detection. Results The main pharmacokinetic parameters of tramadol and M1 in group 2 were not significantly different from those in group 1. There are significant difference for the main pharmacokinetic parameters of tramadol and M1 between group 3 and group 1, group 4 and group 1, group 4 and group 3, respectively (P0.05). Conclusion The present results shown that CYP2D6*2 has no influence on the pharmacokinetics of tramadol, but CYP2D6*10 reduces CYP2D6 activity which leads to the change of phenotype, and the homozygotes has more significant influence on the pharmacokinetics of tramadol than the heterozygotes in Chinese population." @default.
- W2379521567 created "2016-06-24" @default.
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- W2379521567 date "2009-01-01" @default.
- W2379521567 modified "2023-09-28" @default.
- W2379521567 title "Influence of CYP2D6 genetic polymorphism on pharmacokinetics of tramadol in Chinese population" @default.
- W2379521567 hasPublicationYear "2009" @default.
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