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- W2379552013 abstract "OBJECTIVE:To study the reliability of core needle biopsy in evaluating the status of hormone receptor,HER-2and Ki-67in breast cancer,investigate the effects of chemotherapy on these biological factors and the predictive value of these biological factors in neoadjuvant chemotherapy.METHODS:Among the 177cases of breast cancer patients in our department from March 2012to January 2013,the expressions of ER,PR,HER-2and Ki-67were examined by immunohistochemical method between the core needle biopsies and surgical excision specimens in 95patients with NAC.As a control group,we analyzed sample pairs from 82patients without NAC.Pathological response of NAC was assessed using the Miller-Payer system and clinical response of NAC was evaluated by RECIST(response evaluation criteria in solid tumors).RESULTS:The expressions of ER 97.6%(80/82),PR 95.1%(78/82),HER-2 97.6%(80/82)and Ki-67 92.7%(76/82)had good coincidence between the core needle biopsies and surgical excision specimens.Ten(12.4%)of 79patients with NAC showed the ER status modulation in the surgically removed specimen as compared with 2(3.9%)of82patients without NAC,P=0.014.Nineteen(24.0%)of 79patients undergoing NAC appeared PR status alteration in the final surgical specimen,whereas only 4(2.4%)of 82patients without NAC did,P=0.001.The shift of HER-2status was found in 4(5.1%)of 79patients with NAC and in 2(2.4%)of 82patients without NAC,respectively,P=0.379.Thirty(38.0%)of 79patients with NAC and 6(7.3%)of 82patients without NAC showed the Ki-67status changed in the surgically removed specimen,P0.001.The positive rates of ER before and after NAC were 64.6%and 53.2%,P=0.146.The positive rates of PR before and after NAC were 63.3%and 45.6%,P=0.025.The high expression rates of Ki-67before and after NAC were 45.6%and 15.2%,P=0.017.The status of ER,PR had no obvious relation with the efficiency of NAC(P0.05).The efficiency of NAC between the patients with HER-2positive and the patients with HER-2negative was 81.8%and 50.7%,P=0.010.The efficiency of NAC between the patients with high expression of Ki-67and the patients with low expression of Ki-67was 70.2%and 45.5%,P=0.029.CONCLUSIONS:The core needle biopsies have good coincidence with surgical excision specimen in determining the status of ER,PR,HER-2and Ki-67.NAC can change the status of ER,PR and Ki-67.The expression of Ki-67and the positive rate of PR decreased after NAC,while the decrease of ER positive rate showed no statistically significant.NAC had no effect on the status of HER-2.HER-2positive and high expression of Ki-67are correlated to better response with chemotherapy." @default.
- W2379552013 created "2016-06-24" @default.
- W2379552013 creator A5057888185 @default.
- W2379552013 date "2014-01-01" @default.
- W2379552013 modified "2023-09-23" @default.
- W2379552013 title "Evaluation of breast biopsy to HR,HER-2 and Ki-67 and neoadjuvant chemotherapy's effect on them" @default.
- W2379552013 hasPublicationYear "2014" @default.
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