Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379553749> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2379553749 abstract "AIM:To study the single-dose and multi-dose pharmacokinetics and bioavailability of ofloxacin sustained-release tablets in healthy volunteers.METHODS:The plasma concentrations of ofloxacin were determined by a RPHPLC method.The reference or test preparation was given to healthy male volunteers according to an open randomized crossover study. The pharmacokinetic parameters and bioavailability of test preparation were compared with reference preparation.RESULTS:The main pharmacokinetic parameters of the test preparation and the reference preparation,the single-dose were as follows:Cmax were(5382± 1558)and(3419±1034)μg/L,Tmax were(1.7±0.6)and(4.2±1.8)h,t1/2 were(8.2±1.0)and(7.6± 1.8)h,MRT were(8.6±0.9)and(10.3±1.4) h;AUC0-t were(33764±5297)and(31280± 4412)μg·L-1·h,AUC0→∞ were(34643± 5356)and(32642±4257)μg·L-1·h.The relative bioavailability of reference to test preparation was(97.9±12.4)%.There were statistical-ly significant difference about Cmax,Tmax,MRT between the reference preparation and test preparation,but there were no statistically significant difference about t1/2,AUC0-t,AUC0→∞. The 90% confidence limit of AUC0-t and AUC0→∞ between the reference preparation and test preparation were 89.0%- 97.0% and 91.4%-97.8% respectively.The multi-dose were as follows:Cmax were(3732±1502)and(3564±982)μg/L,Cmin were(750±193),(438 ±89)μg/L,Tmax were(1.5±0.5)and(3.7± 1.7)h,AUCSS were(32689±4786)and(33591 ±7929)μg·L-1·h,Cav were(1362±199)and(1405±337)μg/L,DF were(216±76)and(222 ±34)%.The relative bioavailability of reference to test preparation was(102.9±22.5)%.There were no statistically significant difference about Cmax,Cav,AUCSS,DF between the reference preparation and test preparation.The 90%confidence limit of Cmax,AUCSS,Cav and DF were 80.8%-114.6%,89.3%-111.9%,89.5%-112.4% and 93.7%-122.4%.CONCLUSION: The results of statistics analysis showed that the test preparation exhibited sustained-release characteristics,and it was bioequivalent between the test preparation and the reference preparation." @default.
- W2379553749 created "2016-06-24" @default.
- W2379553749 creator A5068762492 @default.
- W2379553749 date "2013-01-01" @default.
- W2379553749 modified "2023-09-26" @default.
- W2379553749 title "Single-dose and multi-dose pharmacokinetics and bioavailability of ofloxacin sustained-release tablets in healthy volunteers" @default.
- W2379553749 hasPublicationYear "2013" @default.
- W2379553749 type Work @default.
- W2379553749 sameAs 2379553749 @default.
- W2379553749 citedByCount "0" @default.
- W2379553749 crossrefType "journal-article" @default.
- W2379553749 hasAuthorship W2379553749A5068762492 @default.
- W2379553749 hasConcept C112705442 @default.
- W2379553749 hasConcept C117671659 @default.
- W2379553749 hasConcept C127413603 @default.
- W2379553749 hasConcept C142724271 @default.
- W2379553749 hasConcept C181389837 @default.
- W2379553749 hasConcept C185592680 @default.
- W2379553749 hasConcept C204787440 @default.
- W2379553749 hasConcept C22979827 @default.
- W2379553749 hasConcept C27081682 @default.
- W2379553749 hasConcept C2778049240 @default.
- W2379553749 hasConcept C2778335254 @default.
- W2379553749 hasConcept C2778512257 @default.
- W2379553749 hasConcept C2992370099 @default.
- W2379553749 hasConcept C42404028 @default.
- W2379553749 hasConcept C43617362 @default.
- W2379553749 hasConcept C501593827 @default.
- W2379553749 hasConcept C55493867 @default.
- W2379553749 hasConcept C71924100 @default.
- W2379553749 hasConcept C87813604 @default.
- W2379553749 hasConcept C98274493 @default.
- W2379553749 hasConceptScore W2379553749C112705442 @default.
- W2379553749 hasConceptScore W2379553749C117671659 @default.
- W2379553749 hasConceptScore W2379553749C127413603 @default.
- W2379553749 hasConceptScore W2379553749C142724271 @default.
- W2379553749 hasConceptScore W2379553749C181389837 @default.
- W2379553749 hasConceptScore W2379553749C185592680 @default.
- W2379553749 hasConceptScore W2379553749C204787440 @default.
- W2379553749 hasConceptScore W2379553749C22979827 @default.
- W2379553749 hasConceptScore W2379553749C27081682 @default.
- W2379553749 hasConceptScore W2379553749C2778049240 @default.
- W2379553749 hasConceptScore W2379553749C2778335254 @default.
- W2379553749 hasConceptScore W2379553749C2778512257 @default.
- W2379553749 hasConceptScore W2379553749C2992370099 @default.
- W2379553749 hasConceptScore W2379553749C42404028 @default.
- W2379553749 hasConceptScore W2379553749C43617362 @default.
- W2379553749 hasConceptScore W2379553749C501593827 @default.
- W2379553749 hasConceptScore W2379553749C55493867 @default.
- W2379553749 hasConceptScore W2379553749C71924100 @default.
- W2379553749 hasConceptScore W2379553749C87813604 @default.
- W2379553749 hasConceptScore W2379553749C98274493 @default.
- W2379553749 hasLocation W23795537491 @default.
- W2379553749 hasOpenAccess W2379553749 @default.
- W2379553749 hasPrimaryLocation W23795537491 @default.
- W2379553749 hasRelatedWork W2028909918 @default.
- W2379553749 hasRelatedWork W2351793767 @default.
- W2379553749 hasRelatedWork W2354859336 @default.
- W2379553749 hasRelatedWork W2360021391 @default.
- W2379553749 hasRelatedWork W2363824840 @default.
- W2379553749 hasRelatedWork W2364317128 @default.
- W2379553749 hasRelatedWork W2364581223 @default.
- W2379553749 hasRelatedWork W2367142317 @default.
- W2379553749 hasRelatedWork W2367703786 @default.
- W2379553749 hasRelatedWork W2369119228 @default.
- W2379553749 hasRelatedWork W2371395769 @default.
- W2379553749 hasRelatedWork W2373350958 @default.
- W2379553749 hasRelatedWork W2375383793 @default.
- W2379553749 hasRelatedWork W2376091005 @default.
- W2379553749 hasRelatedWork W2382788998 @default.
- W2379553749 hasRelatedWork W2388696940 @default.
- W2379553749 hasRelatedWork W2389849983 @default.
- W2379553749 hasRelatedWork W2392374035 @default.
- W2379553749 hasRelatedWork W2393566082 @default.
- W2379553749 hasRelatedWork W3139970622 @default.
- W2379553749 isParatext "false" @default.
- W2379553749 isRetracted "false" @default.
- W2379553749 magId "2379553749" @default.
- W2379553749 workType "article" @default.