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- W2379565522 abstract "Objective:To explore the value of bone alkaline phosphatase in diagnosis of children with vitamin D deficiency rickets and the partial effect factors of serum 25-(OH) D and bone alkaline phosphatase.Methods:551 children aged 4 months～12 years were selected as study objects,and infants accounted for 86.99%.The venous blood samples were abstracted to detect serum 25-(OH) D and bone alkaline phosphatase levels.Results:Serum 25-(OH) D 50 nmol/L was used as the criterion of vitamin D deficiency,when the level of bone alkaline phosphatase was more than 250 U/L,the specificity was 69.01%,the sensitivity was 18.12%,the positive likelihood ratio was 0.58;when the level of bone alkaline phosphatase was more than 300 U/L,the specificity was 95.91%,the sensitivity was 2.50%,the positive likelihood ratio was 0.61.There was significant correlation between serum 25-(OH) D and the intake condition of vitamin D(γ=0.449,P=0.000);there was significant correlation between serum 25-(OH) D and the intake dose of milk powder(γ=0.156,P=0.018);there was no significant correlation between serum 25-(OH) D and bone alkaline phosphatase(γ=0.041,P=0.535).Conclusion:Bone alkaline phosphatase can't simultaneously satisfy high specificity and sensitivity in diagnosis of children with vitamin D deficiency rickets,when the level of bone alkaline phosphatase increases,the specificity increases and the sensitivity decreases;the level of serum 25-(OH) D is closely related to the intake of vitamin D and the intake dose of milk powder." @default.
- W2379565522 created "2016-06-24" @default.
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- W2379565522 date "2011-01-01" @default.
- W2379565522 modified "2023-09-25" @default.
- W2379565522 title "Exploration on the clinical value of bone alkaline phosphatase in diagnosis of children with vitamin D deficiency rickets" @default.
- W2379565522 hasPublicationYear "2011" @default.
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