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- W2379565599 abstract "Objective To study the genetic polymorphisms of cytochrome P450 3A4 (CYP3A4) and the relationship between polymorphisms and susceptibility to hepatocellular carcinoma (HCC). Methods The polymorphisms of CYP3A4 in 84 patients with HCC and 144 healthy controls were detected by PCR-DGGE-Sequence or PCR-SSCP-Sequence. Results Ten exons of CYP3A4 were tested. In 2 cases a transition of A→G at nucleotide 15742 in exon 7 of CYP3A4 was found, this change led to an asparagine at 183rd residue substituted by a serine. A single nucleotide polymorphism (SNP) of transition G→A at nucleotide 20338 was found in intron 10,The frequencies of G/G,G/A and A/A genotypes of cases were 59.52% ,36.90% and 3.58% respectively, while those of controls were 59.72%,33.33% and 6.95% respectively. The difference was not statistically significant. Conclusion CYP3A4 may be a highly conservative gene, mutation is very rare." @default.
- W2379565599 created "2016-06-24" @default.
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- W2379565599 date "2003-01-01" @default.
- W2379565599 modified "2023-09-24" @default.
- W2379565599 title "Genetic polymorphism of Cytochrome P450 3A4 and susceptibility to hepatocellular carcinoma" @default.
- W2379565599 hasPublicationYear "2003" @default.
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