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- W2379573602 abstract "Objective: To investigate the influence of 17β-estradiol on vascular smooth muscle cells(VSMCs)proliferation induced by fetal calf serum and the related mechanism.Methods: The fetal calf serum was used to stimulate cultured VSMCs proliferation(P0.05),and the effects of estrogen on VSMCs proliferation were determined by MTT,and the expressions of caveolin-1 and inducible nitric oxide synthase(iNOS)were also detected by Western blot.Results: Compared with the normal control group,the fetal calf serum could increase the VSMCs proliferation(P0.05),and inhibit proliferation effect of fetal calf serum,pretreated with estradiol for 24 hours(P0.05).Western bolt results further proved that 17β-estradiol inhibited the downregulation of caveolin-1,iNOS and NO induced by fetal calf serum,which was prevented by pretreatment with estrogen antagonist,Tamoxifen(P0.05).Conclusion: 17β-estradiol can inhibit VSMCs proliferation induced by fetal calf serum,and this effect is mediated by estrogen receptor.17β-estradiol increases caveolin-1 and iNOS protein expression,and NO release,leading to the inhibition of VSMCs proliferation induced by fetal calf serum." @default.
- W2379573602 created "2016-06-24" @default.
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- W2379573602 date "2009-01-01" @default.
- W2379573602 modified "2023-09-23" @default.
- W2379573602 title "Influence of 17β-estradiol on Vascular Smooth Muscle Cells Proliferation Induced by Fetal Calf Serum and Its Mechanism" @default.
- W2379573602 hasPublicationYear "2009" @default.
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