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- W2379591934 abstract "Objective To determine whether D543N polymorphisms of the NRAMPI gene are associated with tuberculosis in Hans.Methods D543N polymorphisms of NRAMPl gene were typed by PCR-RFLP among 54 patients with spinal tuberculosis and 60 healthy individuals.The relationship between D543N polymorphisms and susceptibility to tuberculosis was studied,and cases were grouped according to genotypes.Results In the spinal tuberculosis patients,genotype G/G,G/A and A/A were observed in 32(59.3%),21(38.9%)and 1(1.8%)case,respectively.While the genotypes of the healthy controls were G/G in 48(80.0%),G/A in 11(18.3%)and A/A in 1(1.7%)case.The frequency of the genotype G/A was found more often among patients than that in controls and significant association was observed between spinal tuberculosis and D543N polymorphisms(χ2=0.049,P0.05).Conclusion Polymorphisms of D543N locus in NRAMP1 gene might affect their susceptibility to spinal tuberculosis in Han nationality living in China." @default.
- W2379591934 created "2016-06-24" @default.
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- W2379591934 date "2008-01-01" @default.
- W2379591934 modified "2023-09-23" @default.
- W2379591934 title "A study on the association of D543N polymorphisms of NRAMP1 gene with susceptibility to tuberculosisin in Han ethnic" @default.
- W2379591934 hasPublicationYear "2008" @default.
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