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- W2379594869 abstract "Objective To evaluate the effectiveness of samarium-153 lexidronam (153Sm-EDTMP) in the treatment of bone metastases secondary to a variety of primary malignancies. Methods Patients with painful bone metastases were treated with 153Sm-EDTMP 0.8 to 1.0 mCi/kg. Patient and physician evaluations were used to assess pain relief, number of metastatic foci and activity of ROI were used to observe post-therapy change in bone scanning. Results Three hundred and eighty patients were enrolled onto the study. Pain relief was observed in 67. 5% . Persistence of pain relief was seen through 2 to 24 weeks, and the mean relief time is (5.8 ±3.4) weeks. KPS score was higher 10% than pre-therapy. The number of metastatic foci and activity of ROI were less than pre-therapy ( P 0.001). Bone marrow suppression was mild, reversible. Conclusion 153Sm-EDTMP provided relief from pain associated with bone metastases as well as inhibition and disappearance of metastatic foci. As a relief pain drug of bone metastases, Sm-EDTMP is safe and effective." @default.
- W2379594869 created "2016-06-24" @default.
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- W2379594869 date "2005-01-01" @default.
- W2379594869 modified "2023-09-26" @default.
- W2379594869 title "Effectiveness of Samarium-153 Lexidronam in Treating Bone Metastases" @default.
- W2379594869 hasPublicationYear "2005" @default.
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