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- W2379599042 abstract "Objective To explore the differentiation of neural stem cells (NSCs) in hippocampus of rat model of Parkinson's disease (PD).Methods Rat models of PD were made by injection 6-hydroxydopamine (6-OHDA) into striatum. 5-bromodeoxyuridine (Brdu) was injected into the abdomens of PD rats for 14 days before they were killed. The expressions of Brdu/Glial fibrillary acidic protein (GFAP) and Brdu/ Neuronal nuclear antigen (Neun) were determined by immunocytochemistry. The distinctive marker for Brdu/GFAP and Brdu/Neun labeling method was used to determine the phenotype of the differentiated cells.Results After PD models were established, the Brdu/GFAP and Brdu/Neun positive cells appeared at 7 d, increased gradually at 14 d, and peaked at 28 d. In these double labelled cells, Brdu/GFAP positive cells were more than Brdu/Neun positive cells.Conclusions Direct injection of 6-OHDA into the striatum stimulates the proliferation of inherent NSCs in hippocampus of rats. Large amounts of NSCs differentiate into astrocytes and small amounts of them turn into neurons." @default.
- W2379599042 created "2016-06-24" @default.
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- W2379599042 date "2006-01-01" @default.
- W2379599042 modified "2023-09-22" @default.
- W2379599042 title "Study on the differentiation of neural stem cells in hippocampus of rat model of Parkinson's disease" @default.
- W2379599042 hasPublicationYear "2006" @default.
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