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- W2379602011 abstract "Objective To investigate the effect of compound mometasone nasal spray on guinea pigs with allergic rhinitis. Methods Forty allergic rhinitis models were built by using 10% toluenediisocyanate olive oil intranasally,which were then divided into four groups randomly: the model group,the blank group,the test- single group and the test- combination group. The two test groups were given medicine( bilateral nasal, with each side 40 μL) at the eighth day after sensitization and an hour before inspiration,respectively. The guinea pigs were administrated 5 consecutive days a week and then suspended the medicine for 2 days. The treatment lasted for 3 weeks. The other two groups were given 0. 9% NaCl. The effects of the drug on syndrome score,the amount of eosinophile granulocytes( EG),pathological changes and the content of nasal histamine were observed. Results The symptoms of allergic rhinitis,the pathological changes and the amount of EG were effectively inhibited or reduced by compound mometasone nasal spray. However,there was no obvious difference between test- combination and test- single groups in contents of histamine in mucosa. Conclusion Compound mometasone nasal spray has a better effect on treating allergic rhinitis in guinea pigs." @default.
- W2379602011 created "2016-06-24" @default.
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- W2379602011 date "2014-01-01" @default.
- W2379602011 modified "2023-09-23" @default.
- W2379602011 title "Experimental study on the effect of pharmacodynamics of compound mometasone nasal spray on guinea pig with allergic rhinitis" @default.
- W2379602011 hasPublicationYear "2014" @default.
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