Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379620962> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2379620962 abstract "Objective To investigate potential predictive factors of relapse after antiviral treatment in patients with chronic hepatitis C virus(HCV) infection,and explore the temporal characteristics of relapse. Methods One-hundred-and-thirteen patients with chronic HCV received pegylated interferon and ribavirin combination therapy.HCV1 type was treated for 48 weeks and non-HCV1 types were treated for 24 weeks.Serum HCV RNA was measured with real-time quantitative reverse-transcription polymerase chain reaction.HCV genotypes were determined by sequencing of the HCV core-envelope1 region,followed by phylogenic analysis. Results The majority(88.5%,100/113) of patients achieved virological response,and 14.0%(14/100) relapsed after stopping treatment.The rate of relapse was higher for HCV1 infections(21.6%) than for HCV2(13.3%),HCV3(10.3%),or HCV6(5.3%) infections,but the differences were not statistically significant(P=0.345).The rate of relapse was lower in patients ≤40 years old(10.8% vs 40 years old: 20.6%),men(9.8% vs women: 20.5%),and patients with elevated alanine aminotransferase(80 U/mL: 8.6% vs 80 U/mL: 21.4%),but the differences were not statistically significant(P=0.204,P=0.133,and P=0.068,respectively).Patients with higher HCV RNA(14.3%) experienced similar relapse rates to those with lower HCV RNA(13.7%,P=0.936).Patients who achieved complete rapid virological response(8.5%) had lower relapse rate than those with partial rapid virological response(23.1%) and those with no rapid virological response(33.3%),while patients who achieved complete early virological response(13.7%) also had lower relapse rate than those with partial early virological response(50.0%);however,none of the intergroup differences were statistically significant(rapid: P=0.174 and early: P=0.148).Most relapses occured in less than three months after stopping treatment,and no relapses occured more than six months after stopping treatment. Conclusion Relapse in chronic HCV patients occured within six months after discontinuation of pegylated interferon and ribavirin treatment.HCV patients,especially those with HCV1,should be carefully monitored by HCV RNA quantitative examination after stopping treatment to detect recurrence in a timely manner." @default.
- W2379620962 created "2016-06-24" @default.
- W2379620962 creator A5036748646 @default.
- W2379620962 date "2012-01-01" @default.
- W2379620962 modified "2023-09-26" @default.
- W2379620962 title "Regularity of relapse after antiviral treatment in patients with chronic hepatitis C" @default.
- W2379620962 hasPublicationYear "2012" @default.
- W2379620962 type Work @default.
- W2379620962 sameAs 2379620962 @default.
- W2379620962 citedByCount "0" @default.
- W2379620962 crossrefType "journal-article" @default.
- W2379620962 hasAuthorship W2379620962A5036748646 @default.
- W2379620962 hasConcept C126322002 @default.
- W2379620962 hasConcept C203014093 @default.
- W2379620962 hasConcept C2522874641 @default.
- W2379620962 hasConcept C2776178377 @default.
- W2379620962 hasConcept C2776408679 @default.
- W2379620962 hasConcept C2776461080 @default.
- W2379620962 hasConcept C2780040827 @default.
- W2379620962 hasConcept C2992872382 @default.
- W2379620962 hasConcept C3020491458 @default.
- W2379620962 hasConcept C71924100 @default.
- W2379620962 hasConcept C90924648 @default.
- W2379620962 hasConceptScore W2379620962C126322002 @default.
- W2379620962 hasConceptScore W2379620962C203014093 @default.
- W2379620962 hasConceptScore W2379620962C2522874641 @default.
- W2379620962 hasConceptScore W2379620962C2776178377 @default.
- W2379620962 hasConceptScore W2379620962C2776408679 @default.
- W2379620962 hasConceptScore W2379620962C2776461080 @default.
- W2379620962 hasConceptScore W2379620962C2780040827 @default.
- W2379620962 hasConceptScore W2379620962C2992872382 @default.
- W2379620962 hasConceptScore W2379620962C3020491458 @default.
- W2379620962 hasConceptScore W2379620962C71924100 @default.
- W2379620962 hasConceptScore W2379620962C90924648 @default.
- W2379620962 hasLocation W23796209621 @default.
- W2379620962 hasOpenAccess W2379620962 @default.
- W2379620962 hasPrimaryLocation W23796209621 @default.
- W2379620962 hasRelatedWork W1410337922 @default.
- W2379620962 hasRelatedWork W197776227 @default.
- W2379620962 hasRelatedWork W2026945575 @default.
- W2379620962 hasRelatedWork W2040406598 @default.
- W2379620962 hasRelatedWork W2059884249 @default.
- W2379620962 hasRelatedWork W2080399330 @default.
- W2379620962 hasRelatedWork W2085764459 @default.
- W2379620962 hasRelatedWork W21058393 @default.
- W2379620962 hasRelatedWork W2112154978 @default.
- W2379620962 hasRelatedWork W2135364364 @default.
- W2379620962 hasRelatedWork W2167780095 @default.
- W2379620962 hasRelatedWork W2275022689 @default.
- W2379620962 hasRelatedWork W2333085085 @default.
- W2379620962 hasRelatedWork W2338082527 @default.
- W2379620962 hasRelatedWork W2376755857 @default.
- W2379620962 hasRelatedWork W2411597359 @default.
- W2379620962 hasRelatedWork W2948805954 @default.
- W2379620962 hasRelatedWork W3039864458 @default.
- W2379620962 hasRelatedWork W340099506 @default.
- W2379620962 hasRelatedWork W2787465921 @default.
- W2379620962 isParatext "false" @default.
- W2379620962 isRetracted "false" @default.
- W2379620962 magId "2379620962" @default.
- W2379620962 workType "article" @default.