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- W2379642711 abstract "Objective:To establish methods for the detection of physical and chemical characteristics of the polymorphs of articaine hydrochloride crystals. Methods: Two polymorphic forms of arti caine hydrochloride crystals were obtained. The polymorphs of articaine hydrochloride crystals were determined by melting point,differential scanning calorimetry (DSC), IR spectra (IR) and powder X-ray diffraction. The stability of the two polymorphs was measured under heat,light and humidity. Results: Two polymorphs of articaine hydrochloride crystals were defined as form Ⅰ and form Ⅱ. The two polymorphic forms showed different melting points, DSC, IR,and powder X-ray diffraction patterns. The form Ⅰ had higher hygroscopicity than the form Ⅱ. Conclusion: Form Ⅱ is more stable form a gainst humidity,and suitable to be a drug substance." @default.
- W2379642711 created "2016-06-24" @default.
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- W2379642711 date "2004-01-01" @default.
- W2379642711 modified "2023-09-26" @default.
- W2379642711 title "Study on the polymorphism of articaine hydrochloride" @default.
- W2379642711 hasPublicationYear "2004" @default.
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